New research goes some way to explaining why the diabetic drug is all the rage.
Metformin has been a hot topic around the fitness traps for a few years. Social media is full of longevity experts and health experts spruiking its benefits, and everyone with a lab coat or a blog is jumping on board for the .02 worth, including me. I am because I’ve been taking it for a few years, on medical advice, and my blood sugar has dropped and I’ve definitely lost weight. But am I going to live longer and avoid cancer like Havard Professor Dr. David Sinclair or neuroscientist Andrew Huberman?
Proponents are making some big claims about the diabetic drug’s benefits, such as its ability to extend life and protect against a panoply of diseases, like cancer. That’s a big call. Swallow a pill every day, and you’ll live a longer life and be less prone to disease. Yes, please. Who wouldn’t want that? Why isn’t it on sale at chemists everywhere, like it is in Thailand? Why is the government handing these things out like pingers on a private yacht?
It gets better. The other big call is that it’s purported to have an almost magical ability to shed weight. In fact, studies show a consistently moderate weight loss for most people who take it over a long period. Some people who take it report that it makes weight come off quickly and boast of Ozempic-like results.
G. officinalis, the herbal lineage of metformin, is also known in Australia as goat’s rue, French lilac, or professor weed. This plant was used as a traditional medicine in medieval Europe
Well hallelujah! A recent study conducted by researchers from Stanford Medicine and Harvard Medical School has shed light on how the diabetes medication metformin induces weight loss by triggering the production of a molecule called lac-phe. This discovery highlights the importance of lac-phe in regulating metabolism, exercise, and appetite, going some way to explaining the myth behind Metformin.
Previously, the mechanism by which metformin, commonly prescribed to manage blood sugar levels, promotes weight loss has been unclear. The study, published in Nature Metabolism, reveals that metformin operates through the same pathway as vigorous exercise to reduce hunger, thus leading to weight loss.
Do you know the feeling after a huge workout, when even a shake has to be forced down? Like the idea of eating is revolting. That is a molecule called lac-phe doing its thing.
Lead authors Jonathan Long, PhD, and Mark Benson, MD, PhD, and their team, found that lac-phe, a molecule discovered in 2022, plays a crucial role in curbing hunger post-exercise. This molecule, formed from lactate and phenylalanine, decreases appetite immediately after intense physical activity.
The study involved experiments with obese mice that were administered metformin, which increased lac-phe levels in their blood. These mice exhibited reduced food intake and lost weight over a nine-day period. Similarly, analysis of blood samples from individuals with Type 2 diabetes before and after metformin treatment revealed elevated lac-phe levels following medication.
Further investigation demonstrated that lac-phe is produced by intestinal epithelial cells. Inhibiting lac-phe production in mice reversed the appetite suppression and weight loss effects observed previously. Additionally, participants’ analysis in an atherosclerosis study revealed a significant association between metformin use, lac-the production, and weight loss.
The study suggests that metformin’s impact on lac-phe production may optimize oral medications to influence hunger and energy balance pathways, potentially improving weight management, cholesterol levels, and blood pressure.
The research heaps more evidence on the side of those who claim it’s multiple benefits.